Accelerates HCV - induced Impairment of Innate Immunity By 1 Suppressing Methylation Reactions in Liver Cells
نویسندگان
چکیده
Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, 5 Omaha, NE 68105, USA, 6 Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 7 68105, USA, 8 School of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68105, USA 9 Department of Pharmacology and Experimental Neuroscience, Omaha, NE 68105, 10 USA 11 Short running title: Acetaldehyde, HCV and innate immunity 12 Corresponding author: 13
منابع مشابه
Acetaldehyde accelerates HCV-induced impairment of innate immunity by suppressing methylation reactions in liver cells.
Alcohol exposure worsens the course and outcomes of hepatitis C virus (HCV) infection. Activation of protective antiviral genes is induced by IFN-α signaling, which is altered in liver cells by either HCV or ethanol exposure. However, the mechanisms of the combined effects of HCV and ethanol metabolism in IFN-α signaling modulation are not well elucidated. Here, we explored a possibility that e...
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